Learn pharmacokinetics
PK simulator
One-compartment model with linear elimination. Pick a preset or enter your own values; everything recalculates as you type.
How the simulator works
The simulator uses a one-compartment model. After an IV bolus, concentration falls exponentially with the elimination rate constant k = CL / V. An infusion rises towards a plateau while it runs, then falls. An oral dose is absorbed with a first-order rate constant ka and scaled by bioavailability F.
Multiple doses are added together (superposition), so you can watch levels accumulate towards steady state. Each tile shows a value you would calculate by hand in a PK course.
Share any regimen with the Copy share link button, or download the curve as CSV for a spreadsheet. The simulator is for teaching only and must not be used to dose real patients.
Learn the concepts
Half-life
What elimination half-life means, how to calculate it from clearance and volume, and why it decides dosing frequency.
Steady state
Why repeated doses build up, why steady state takes about five half-lives, and what accumulation ratio means.
Area under the curve (AUC)
What AUC measures, how it relates to dose, bioavailability and clearance, and why vancomycin dosing now targets AUC.
Bioavailability
Oral bioavailability (F), first-pass metabolism, and why IV and oral doses of the same drug differ.
Loading dose
When and why a larger first dose is used, and how to calculate it from volume and target concentration.
Pro for educators
Teaching with the simulator?
Join the waitlist for classroom mode, saved scenarios and printable worksheets.
